Promoting Tissue Healing
Hyaluronic acid (HA)
▪ promote cell spreading
▪ promote production of stress fiber
▪ provide a suitable site for cell proliferation
Carboxymethyl chitosan (CMC)
▪ nourish chondrocyte(Only cell in our cartilage)
▪ promote the proliferation of chondrocyte,
▪ delaying the degeneration of chondrocyte
▪ inhibiting the apoptosis of chondrocyte in arthritis.
▪ promote the growth of skin fibroblasts and epidermal
keratinocytes then promote wound healing.
Where to use it
1. General surgery 2. Thoracic surgery 3. Gastroenterology 4. Cardiac surgery
5. Obstetrics and Gynecology 6. Neurosurgery 7. Urology 8. Endoscopic Surgery
9. OrthopaedicsEtc.
Thoracic Surgery
1) Soft and resilient; 2) Strong adhesion.
E.g. Pulmonary surgery
Strongly adhere to lung surface and do not fall off as lungs contracting and expanding.
Effective stop bleeding and close section surface.
Reduce the risk of air leakage and infection.
E.g. Cardiac surgery
Soft texture would not harm any organ.
Prevent bleeding and adhesion between heart and pericardium.
Stop bleeding at chest wall before chest closure.
E.g. Mediastinal tumor surgery
Prevent abnormal adhesion of intrathoracic tissue.
Prevent blood or lymphatic leakage.
Generations of Topical Hemostatic Agents
ORC |Surgicel , Johnson & Johnson
▪ Plant-based material, Oxidized regenerated cellulose
▪ From 1960s
▪ Mechanism: Physical pressure to stop bleeding
▪ No risks of allergy reaction
▪ 7-14 days, but incomplete degradable, residues
found in reoperation after 5 years and 9 months
▪ Leaves an acid environment
▪ Not recommended in Orthopedics, Neurosurgery and Obstetrics.
Product comparison -- Hemostasis
Product comparison – Anti-Adhesion
