Promoting Tissue Healing
Hyaluronic acid (HA)
▪ promote cell spreading
▪ promote production of stress fiber
▪ provide a suitable site for cell proliferation
Carboxymethyl chitosan (CMC)
▪ nourish chondrocyte(Only cell in our cartilage)
▪ promote the proliferation of chondrocyte,
▪ delaying the degeneration of chondrocyte
▪ inhibiting the apoptosis of chondrocyte in arthritis.
▪ promote the growth of skin fibroblasts and epidermal
keratinocytes then promote wound healing.
Where to use it
1. General surgery 2. Thoracic surgery 3. Gastroenterology 4. Cardiac surgery
5. Obstetrics and Gynecology 6. Neurosurgery 7. Urology 8. Endoscopic Surgery
9. OrthopaedicsEtc.
General Surgery
1) Prevent post surgical adhesion
Prevent adhesion between tendon and tissue. Ensure the flexibility of joints.
2) Prevent lymphatic leakage
E.g. Mammary cancer
Lymphatic leakage can be avoided.
3) Prevent fistula generation
E.g. Gastroenterostomy
Prevent anastomotic fistula which would cause infection.
4) Protect nerve cells and tissues
E.g. ENT surgery
Prevent recurrent laryngeal nerve delayed injury by protecting nerve during procedure using Biopaper and
prevent adhesion simultaneously.
Generations of Topical Hemostatic Agents
ORC |Surgicel , Johnson & Johnson
▪ Plant-based material, Oxidized regenerated cellulose
▪ From 1960s
▪ Mechanism: Physical pressure to stop bleeding
▪ No risks of allergy reaction
▪ 7-14 days, but incomplete degradable, residues
found in reoperation after 5 years and 9 months
▪ Leaves an acid environment
▪ Not recommended in Orthopedics, Neurosurgery and Obstetrics.
Product comparison -- Hemostasis
Product comparison – Anti-Adhesion
